713: Incidence and Outcomes of Hyperchloremia Subsequent to Hypertonic Saline for Intracranial Pressure

Hypertonic saline for cerebral edema and elevated intracranial pressure.

The use of HS solutions has been shown to reduce ICP both in animal models and in human studies in a variety of underlying disorders, even in cases refractory to treatment with hyperventilation and mannitol. There are several possible mechanisms of action, and important complications such as central pontine myelinolysis and intracranial hemorrhage have not been reported in the human studies. Di...

Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis.

OBJECT Currently, mannitol is the recommended first choice for a hyperosmolar agent for use in patients with elevated intracranial pressure (ICP). Some authors have argued that hypertonic saline (HTS) might be a more effective agent; however, there is no consensus as to appropriate indications for use, the best concentration, and the best method of delivery. To answer these questions better, th...

Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis A review

210 J Neurosurg / Volume 116 / January 2012 INTRACRANIAL hypertension following neurological injury is often associated with poor outcomes.13 Increased ICP reduces CBF and can lead to brain herniation and death. The Brain Trauma Foundation has recommended that therapy to reduce ICP should begin at pressures > 20 mm Hg. Hyperosmolar therapy is a commonly used treatment for intracranial hypertens...

Effects of hypertonic saline on intracranial pressure variables in subarachnoid haemorrhage patients

Effects of hypertonic (10%) saline in patients with raised intracranial pressure after stroke.

BACKGROUND AND PURPOSE The aim of this study was to evaluate the effects of hypertonic saline in stroke patients with increased intracranial pressure (ICP) after conventional therapy with mannitol had failed. METHODS Twenty-two episodes of ICP crisis occurred in 8 patients in whom the standard treatment of 200 mL of 20% mannitol was not effective. ICP crisis was defined as an increase in ICP ...